A Special Report on Vitamin D3 sulfate

A Special Report on “Vitamin D3 Sulfate

A Game Changer – The vitamin D formed on the skin from exposure to UVB rays from the sun or a tanning bed produces “Vitamin D3 Sulfate,” a form that is different and has far more health benefits than vitamin D3 (or D2)

C. LeBeau.

For years I have had personal doubts that the vitamin D3 in capsule form had the same health benefits as the vitamin D produced by sunlight or ultraviolet light from a sun tanning bed. One example – I have long observed that vitamin D capsules did not improve my quality of sleep whereas sunlight and tanning beds did, and that is just the tip of the iceberg. The research and paradigm by Dr Seneff on how sunlight on the skin produces vitamin D3 sulfate is truly a game changer. You cannot buy vitamin D3 sulfate in pill form. It must be produced by the effects of UVB rays reaching your skin. Dr Seneff explains the process in the following articles.

An article I saved on my computer from 2011 strengthens my own theory that vitamin D3 as a supplement does not replace the sulfated form of vitamin D that you get directly from sunlight or from ultraviolet light in a tanning bed. In fact, Dr Seneff turns the existing paradigm about vitamin D, sunlight, cholesterol and the immune system on its head. This article is a game changer and the implications are profound that the use of statin drugs or relying on vitamin D pills alone as a substitute for sunlight may short change you out of the many benefits from raising your blood serum levels of vitamin D. Even more alarming, Vitamin D2 or D3 in high doses may even contribute to hardening of the arteries when used long term.


An article by Dr. Seneff published by the Weston A Price Fdn

Dr. Seneff:

“The evidence is quite compelling that sunny places afford protection from heart disease. A study described in a 1996 issue of QJ Med. provides an in-depth analysis of data from around the world showing an inverse relationship between heart disease rates and a sunny climate and a low latitude. For instance, the cardiovascular-related death rate for men between the ages of 55 and 64 was 761 per 100,000 men in Belfast, Northern Ireland, but only 175 in Toulouse, France. While the obvious biological factor that would be affected by sunlight is vitamin D, studies conducted specifically on vitamin D status have been inconclusive, with some even showing a significant increased risk for heart disease with increased intake of vitamin D2 supplements.

“I believe, first of all, that the distinction between vitamin D3 and vitamin D3 sulfate really matters, and also that the distinction between vitamin D2 and vitamin D3 really matters. Vitamin D2 is the plant form of the vitamin. It works similarly to D3 with respect to calcium transport, but it cannot be sulfated. Furthermore, apparently the body is unable to produce vitamin D3 sulfate directly from unsulfated vitamin D3  (which implies that it produces vitamin D3 sulfate directly from cholesterol sulfate). I am not aware of any other food source besides raw milk that contains vitamin D3 in the sulfated form. So, when studies monitor either vitamin D supplements or vitamin D serum levels, they’re not getting at the crucial aspect for heart protection, which I think is the serum level of vitamin D3 sulfate.

“Furthermore, I believe it is extremely likely that vitamin D3 sulfate is not the only thing that’s affected by greater sun exposure, and maybe not even the most important thing. Given that cholesterol sulfate and vitamin D3 sulfate are very similar in molecular structure, I would imagine that both molecules are produced the same way. And since vitamin D3 sulfate synthesis requires sun exposure, I suspect that cholesterol sulfate synthesis may also exploit the sun’s radiation energy.

“Both cholesterol and sulfur afford protection in the skin from radiation damage to the cell’s DNA, the kind of damage that can lead to skin cancer. Cholesterol and sulfur become oxidized upon exposure to the high frequency rays in sunlight, thus acting as antioxidants to “take the heat,” so to speak. Oxidation of cholesterol is the first step in the process by which cholesterol transforms itself into vitamin D3. Sulfur dioxide in the air is converted non-enzymatically to the sulfate ion upon sun exposure. This is the process that produces acid rain.

“The oxidation of sulfide (S-2) to sulfate (SO4-2), a strongly endothermic reaction15, converts the sun’s energy into chemical energy contained in the sulfur-oxygen bonds, while simultaneously picking up four oxygen molecules. Attaching the sulfate ion to cholesterol or vitamin D3is an ingenious step, because it makes these molecules water-soluble and therefore easily transportable through the blood stream.

“Hydrogen sulfide (H2S) is consistently found in the blood stream in small amounts. As a gas, it can diffuse into the air from capillaries close to the skin’s surface. So it is conceivable that we rely on bacteria in the skin to convert sulfide to sulfate. It would not be the first time that humans have struck up a symbiotic relationship with bacteria. If this is true, then washing the skin with antibiotic soap is a bad idea. Photo-trophic bacteria, such as Chlorobium tepidum, that can convert H2S to H2SO4 exist in nature39,36, for example in sulfur hot springs in Yellowstone Park. These highly specialized bacteria can convert the light energy from the sun into chemical energy in the sulfate ion.

“Another possibility is that we have specialized cells in the skin, possibly the keratinocytes, that are able to exploit sunlight to convert sulfide to sulfate, using a similar photo trophic mechanism to C. tepidum. This seems quite plausible, especially considering that both human keratinocytes and C. tepidum can synthesize an interesting UV-B absorbing cofactor, tetrahydrobioptin. This cofactor is found universally in mammalian cells, and one of its roles is to regulate the synthesis of melanin, the skin pigment that is associated with a tan and protects the skin from damage by UV-light exposure.9 However, tetrahydrobiopsin is very rare in the bacterial kingdom, and C. tepidum is one of the very few bacteria that can synthesize it.

“Let me summarize at this point where I’m on solid ground and where I’m speculating. It is undisputed that the skin synthesizes cholesterol sulfate in large amounts, and it has been suggested that the skin is the major supplier of cholesterol sulfate to the blood stream. The skin also synthesizes vitamin D3 sulfate upon exposure to sunlight. Vitamin D3 is synthesized from cholesterol, with oxysterols (created from sun exposure) as an intermediate step (oxysterols are forms of cholesterol with hydroxyl groups attached at various places in the carbon chain). The body can’t synthesize vitamin D3 sulfate from vitamin D3 so it must be that sulfation happens first, producing cholesterol sulfate or hydroxy-cholesterol sulfate, which is then optionally converted to vitamin D3 sulfate or shipped out “as is.”

“Another highly significant feature of skin cells is that the skin stores sulfate ions attached to molecules that are universally present in the intracellular matrix, such as heparin sulfate, chondroitin sulfate, and keratin sulfate. Furthermore, it has been shown that exposure of the melanin-producing cells (melanocytes) to molecules containing reduced sulfur (-2) leads to suppression of melanin synthesis, whereas exposure to molecules like chondroitin sulfate that contain oxidized sulfur (+6) leads to enhancement of melanin synthesis.

“Melanin is a potent UV-light absorber, and it would compete with reduced sulfur for the opportunity to become oxidized. It is therefore logical that, when sulfur is reduced, melanin synthesis should be suppressed, so that sulfur can absorb the solar energy and convert it to very useful chemical bonds in the sulfate ion.

“The sulfate would eventually be converted back to sulfide by a muscle cell in the heart or a skeletal muscle (simultaneously recovering the energy to fuel the cell and unlocking the oxygen to support aerobic metabolism of glucose), and the cycle would continually repeat.

“Why am I spending so much time talking about all of this? Well, if I’m right, then the skin can be viewed as a solar-powered battery for the heart, and that is a remarkable concept. The energy in sunlight is converted into chemical energy in the oxygen-sulfur bonds, and then transported through the blood vessels to the heart and skeletal muscles. The cholesterol sulfate and vitamin D3-sufate are carriers that deliver the energy (and the oxygen) “door-to-door” to the individual heart and skeletal muscle cells.

“Today’s lifestyle, especially in America, severely stresses this system. First of all, most Americans believe that any food containing cholesterol is unhealthy, so the diet is extremely low in cholesterol. Eggs are an excellent source of sulfur, but because of their high cholesterol content we have been advised to eat them sparingly. Second, as I discussed previously, natural food plant sources of sulfur are likely to be deficient due to sulfur depletion in the soil. Third, water softeners remove sulfur from our water supply, which would otherwise be a good source. Fourth, we have been discouraged from eating too much red meat, an excellent source of sulfur-containing amino acids. Finally, we have been instructed by doctors and other authoritarian sources to stay out of the sun and wear high SPF sunscreen whenever we do get sun exposure.

“Another significant contributor is the high carbohydrate, low-fat diet, which leads to excess glucose in the blood stream, which glycates LDL particles and renders them ineffective in delivering cholesterol to the tissues. One of those tissues is the skin, so skin becomes further depleted in cholesterol due to glycation damage to LDL.

For the complete article by Dr Seneff, go to the Weston A Price Fdn at https://www.westonaprice.org/health-topics/abcs-of-nutrition/sulfur-deficiency

For an expanded article by Dr Senoff on vitamin D3 sulfate, go  to keephopealive.org.

E-Cole Outbreak leads to Romaine Lettuce Recall

Washing fruits and vegetables with ozonated water would stop  bacteria and parasite contamination

Conrad LeBeau

The FDA has advised the public to throw out all their Romaine lettuce unless they know it did not come from Yuma AZ, believed to be the source of e-coli contamination. The problem of fruits or vegetables contaminated with e-coli, salmonella, hepatitis B or other pathogens is that it is a recurring national problem and leads to very economically wasteful recalls. America’s farmers, who barely eek out a living with their hard labor, bear the brunt of these expenses.

The problem of contamination of vegetables or fruit with pathogens that can cause illness and even death is not limited to occasional outbreaks in the United States, but includes products imported from Mexico and other countries. There are multiple points of intersection in the food supply chain where the washing of fruits and vegetables with ozonated water would end these bacteria, parasites or other pathogen outbreaks.

            The points of intervention of the fresh food supply chain are –

  1. Farms- washing fruits and vegetables with ozonated water before they are shipped.
  2. Washing fresh foods with ozonated water at major distribution centers.
  3. Grocery stores that already spray many of their vegetables with water should add ozone to the water supply to kill any remaining bacteria or parasites that might remain.
  4. Prepackaged fruits and vegetables could be labeled as having been washed with ozonated water, and thus safe to eat and not subject to recalls. Millions of dollars in wasted fresh food inventory could thus be saved and many lives could be protected from food borne contamination.

The Ozone Solution to e-coli and other pathogen outbreaks

Ozone could make fruits and vegetables nearly 100% safe for all Americans. Ozone is an electrically charged form of oxygen. Oxygen is normally O2. With the use of electrodes through which oxygen or air is passed, the O2 becomes O3, O4, O5 and O6. As the electrons are released from the electrically charged oxygen atoms, they zap bacteria, fungus, viruses and other pathogens. The Ozone then is reduced back to its natural O2 form, which is in the air we breathe. Even if there are no pathogens to zap, ozone naturally has a short half-life and converts back to its stable O2 form within a few hours.

Milwaukee ended its 1993 cryptosporidium problem with Ozone

Ozone is one of the most safe and effective anti-microbial agents known to man. Some cities have added ozone to the purification of their water supple to protect the public from water borne microbes. In April 1993, 403,000 people in Milwaukee were afflicted with a watery diarrhea caused by the parasite – cryptosporidium.  The city found the source of the problem on April 7th – its own water supply was infected with the parasite. Eventually, 69 people died from this outbreak.

Under the leadership of Mayor John Norquist, the city undertook a number of measures to better purify and better protect the water supply from pathogens and thus the public. For the past 25 years, the city’s water has been free from of this parasite and Milwaukee’s use of ozone has made it the safest city water in the nation.


A source of commercial ozonating equipment for grocery stores, distributors and farmers.

            Ozotech has manufactured Ozone equipment for the past 30 years and has a wide range of products made solely here in the United States. This includes small unites that cost a few hundred dollars to large unites for factories and farms and even equipment to disinfect the city’s municipal water supply. A technical expert at Ozotech told me they have a unit called PR220PRO that adds sufficient ozone to water that circulates through it to disinfect any fruits or vegetables that are sprayed with the ozonated water. This unit will spray about .78 Gallons per minute with an ozone concentration greater than .4 parts per million (ppm). Ozotech’s test have found that every pathogen is killed when subjected to ozonated water greater than .4 ppm. This unit sells for around $1900.

Household Ozone Equipment.

            In 1991, I purchased an ozone unit from Ozotech Model OZ2PCS for around $600. It is still working great and has never needed repairs. I attached an oxygen tank to it along with a regulator and generally set the flow rate at ½ liter per minute.

A new lower cost model suitable for household use that takes up very little space and can be wall mounted is the Ozotech Poseidon 220 Ozone Generator. It sells for about $245. Maximum output is 220 mg ozone per hour. With an oxygen tack attached the output of ozone increases 4 fold to over 800 mg hr.This is the unit I would buy if and when I ever need another one. For more information, you can contact Ozotech through their website or to find a distributor near you. This unit will work well with either an Aquarium air pump attached or by improvising an oxygen tank by adding a regulator to control volume.

If used to clean an aquarium, you simply attach it to a Ventura that has a vacuum to the circulating air pump and draws the ozone into the circulating water. To use the Ozone unit for other personal purposes, you will either need either an air pump that has an output of 2 liters or less per minute or an oxygen tank and a regulator. The air pumps for aquariums cost less than $6.00 online. Running the ozone gas through a gallon of water for 10 minutes should not only disinfect the water but also any fruits or vegetables you place in the container. You can also drink the ozonated water for treating intestinal infections or use it in enema water to disinfect and clean the colon.

Small oxygen tanks can be obtained for less that $10 each from local hardware stores. They are usually next to the small propane tanks. An oxygen tank regulator for these small tanks can be found online at places that sell equipment for brewing beer and wine. The valve is screwed onto to a small portable oxygen tank (Benzomatic etc) you can find at any hardware store. A plastic hose is attached to the barbed outlet of the valve and is connected to the inlet tube of the Ozone machine. Before permanently attaching to the Ozone machine, place the tube into to a 1 liter or quart plastic bag and adjust the oxygen flow to fill up the bag in 1 to 2 minutes. Then mark the airflow position with an indelible ink pen and connect the hose from the oxygen tank to the air inlet side of the Ozone unit.

This is not a perfect way to measure airflow but it is low cost way to regulate the flow of oxygen. Otherwise, you may need to buy a regulator for the oxygen tank and some types require a prescription. This way, no prescription is needed and the oxygen in the small tanks works just fine for ozonating water to disinfect vegetables and for making ozonated water for use in colonics. I have also used an oxygen tank – the kind used by welders, as a source of oxygen for ozonating drinking water for several years. All you need to do is add a small inline air filter (from an auto parts dealer) to the output of the oxygen tank to remove any metal flakes that might come off the inside of the tank when in use and that gives you the equivalent of medical grade oxygen without the extra expenses.

Other Household methods to disinfect fresh fruits and vegetables.

            There are several ways to disinfect fruits and vegetables. Besides throwing them out or cooking them, they include the following

  1. Hydrogen Peroxide: Besides using ozonated water, fruits and vegetables may be washed with a diluted solution of hydrogen peroxide and water. Add one tablespoon of 3% H2O2 to a pint of water and spray the fruits and vegetables with this solution or place fill the sink with water and add 1/4 cup of hydrogen peroxide to the sink. Dip the fresh foods into the water. Let them stand for 5 minutes and rinse off with cold water.
  2. Grapefruit seed extractor OTC Vegetable Wash: Use as directed on the label.
  3. Vinegar – any vinegar will work – apple cider, white distilled or red wine vinegar. Spray or dip the vegetables into the vinegar and package them in fresh plastic bags. Leave the vinegar on – it pre-seasons lettuce and other vegetables for eating. If vinegar is used on fruit, wash it the vinegar after 3 minute as it may add a sour taste to some fruits. If you prefer, also wash the vinegar off vegetables before eating.

For more information, find an integrative doctor trained in bio-oxidative medicine at acam.org or search online. Information on ozone is also found in the Immune Restoration Handbook 3rdedition and online at keephopealive.org.