by Tim Horn, Senior Writer & Editor, AIDSmeds.com
HIV's ability to damage the human immune system might amount to an accident of evolution, notably the loss of the protective function of a viral protein called Nef. Like HIV in humans, related strains of simian immunodeficiency virus (SIV) are rampant among many species of monkeys. Unlike HIV in humans, many primates infected with SIV don't experience immune suppression or suffer the symptoms associated with AIDS.
The evidence, published by an international team of researchers in the June 2006 issue of Cell, is the first to offer an explanation for this striking difference. The group found that a viral protein known to help the virus evade the immune system, thereby allowing the SIVs that infect monkeys to persist and multiply with high efficiency, also has a protective role in the host immune system. The SIV Nef protein ratchets down the activation of T-cells following infection in primates, thereby limiting the harmful effects that can be caused by chronically strong immune activation.
While chronically strong immune activation may seem like a good thing when it comes to fighting HIV infection, it ends up causing the death of many T-cells and ultimately exhausts the immune system - two factors that can lead to AIDS.
The HIV Nef protein, and those of its closest related simian viruses, however, lack this protective function, leaving those infected susceptible to the heightened immune activation associated with progression to AIDS, according to the new research.
"Nef-mediated suppression of T-cell activation is a fundamental property of primate lentiviruses that likely evolved to maintain viral persistence in the context of an intact host immune system," Dr. Frank Kirchhoff of the University of Ulm in Germany said. "The findings suggest that the gene function was lost during viral evolution in a lineage that gave rise to HIV-1 and may have predisposed the simian precursor of HIV-1 for greater pathogenicity in humans."
"Heightened immune activation is the only clear-cut difference between pathogenic and non-pathogenic infections with the immunodeficiency viruses," Dr. Kirchhoff added. "The observed difference in Nef function may provide, for the first time, a mechanism to explain why many monkey species naturally infected with SIV do not develop disease."
Study coauthor Dr. Beatrice Hahn of the University of Alabama has previously shown that the two forms of HIV that infect humans originated from related SIVs found in different species of African.
HIV-1 - most closely related to an SIV strain found in chimpanzees - is the more virulent of the two human strains and the source of the majority of HIV infections throughout the world. The less pathogenic HIV-2 evolved from a virus that infects long-tailed relatives of baboons called sooty mangabeys. While HIV and SIV strains all infect T-cells that are critical for a functional immune response, SIV usually does so without causing serious damage in their natural primate hosts.
Of more than 30 SIVs that have been molecularly characterized, all encode a Nef gene. However, information about the gene's function has come from studies involving the HIV-1 version of Nef. In turn, Dr. Kirchhoff and his group examined Nef genes taken from a variety of SIV types.
According to the research conducted by Dr. Kirchhoff's group, Nef variants from the great majority of primate SIVs, including the less virulent human strain HIV-2, suppress the expression of a receptor normally found on the surface of T-cells, making the immune cells less responsive to activation. In contrast, the Nef gene of HIV-1 and a subset of closely related SIVs failed to limit T-cell activation and death.
"Intriguingly, this loss of Nef-mediated suppression of T cell activation appears to have occurred twice, once in the ancestor of a group of viruses infecting Cercopithecus monkeys, and once in SIVcpz, the ancestor of HIV-1 which infects chimpanzees," noted study coauthor Dr. Paul Sharp, of the University of Nottingham, who is a leading expert in HIV and SIV evolution.
"What these viruses have in common is a Vpu gene, not found in other SIVs, and so it's tempting to speculate that the presence of Vpu is somehow causally related to the change in Nef function," Dr. Sharp added.
The findings expand on previous studies that found that Nef-deficient SIV failed to cause symptoms in a monkey species normally susceptible to disease.
Other researchers have reported in the past that rhesus macaques infected with the Nef-deficient virus had extremely low viral loads and limited evidence of disease progression. Similarly, humans infected with Nef-defective HIV progress to disease symptoms slowly, if at all.
While altering HIV's Nef gene may not be a therapeutic possibility for those infected with the virus, these results - along with research conducted by several other teams - suggest the use of treatments that could carefully limit immune system activation in humans. This, Dr. Kirchhoff says, would mimic the tight immune system-virus balance seen in non-human primates.
"A strong immune response can be good in the short term, but if sustained for a long time as in those with HIV, it can exhaust the immune system," Dr, Kirchhoff said. "If you could somehow dampen the response, it might effectively convert the condition to the more chronic, asymptomatic infection seen in monkeys." Source:
I could not agree more with Dr. Kirchhoff statement that "Heightened immune activation is the only clear-cut difference between pathogenic and non-pathogenic infections with the immunodeficiency viruses," The implications of this latest published research are profound. Will doctors now appreciate the potential benefits of using low dose immuno-suppressive drugs to stop HIV progression to AIDS in humans? Clearly low dose glucocorticoids (prednisolone, hydrocortisone) can mimic the effects of the SIV nef gene in monkeys who remain healthy in spite of their high viral loads.
We wrote in Positive Health New Report No 18 in "A Search for TH1" in the Spring of 1999 that the immune system was out of balance in AIDS with suppressed cell mediated immunity and overactive Humoral (TH2) immune responses.
For several years we tried to stimulate cell mediated immunity with only moderate success. We did not realize at that time that we had to suppress the TH2 arm (antibody) arm of the immune response to see real progress in restoring CD4 cells to their proper level and function.
To stop HIV progression to AIDS, we needed to find a way to suppress and control the inflammatory cytokines that drive the TH2 arm of the immune system. The inflammatory cytokines we know about today are NF-Kappa B, TNF-a and IL-6 but there could be more that will be discovered in due time. It was not only Alfred Plechner, DVM, whose 30 plus years of treating over 35,000 dogs, cats and other pets with prednisolone and thyroid that finally opened our eyes to scrapping the disease model of the past 25 years that HIV is pathogenic and directly causes immune deficiency but also the research in Germany of Albrecht Ulmer et al in a controlled study that demonstrated that even a low dose of just 5 mg daily of prednisolone could single handedly keep the CD4 counts high and AIDS at bay over a 2 year period.
Ulmer, who has published over 166 articles in peer reviewed medical journals, did not hype the results of his study, but we are and for good cause. Just one headline story about the amazing benefits of immunotherapy (low-dose glucocorticoids) in treating AIDS in any one of our major media (CNN, MSNBC, FOX, ABC, CBS, NBC etc) would have a worldwide impact and could open minds globally on new treatment options that could save millions of lives. The 1980s motto of ACT-UP that "Silence = death" is true, but where have all the soldiers gone?
There are the studies of the National Institute of Health in the 1990's that short term use of high dose prednisone could more than double the CD4 counts in as little as 3 weeks. Unfortunately, research with low cost immunotherapy using glucocorticoids stopped and research with low dose glucocorticoids never started.
We are trying to present a new disease model because someone has to do it. So many people, including ourselves got it wrong in the past 25 years. We thought HIV was pathogenic, that is it would attack and destroy CD4 cells, the Generals of the immune system. We though HIV was an immunodeficiency virus and AIDS were an immunodeficiency disease. We were wrong but we learned to evolve our understanding of this illness by having an open mind and searching for definitive cause and effect relationships.
What we have found is that HIV is not an immunodeficiency virus, it is a Humoral Overactivity Virus or abbreviated as HOV. The tragic mistake today is that doctors and the pharmaceutical drugs they use to treat AIDS is not as a disease of the immune system, but as a viral infection. After 10 years of HAART with protease inhibitors used in combination with reverse transcriptase inhibitors and NNRTIs, nearly half of all patients now believe that the side effects of the drugs are as bad if not worse than the HIV virus.
HIV should be called HOV or humoral overactivity virus as it over-stimulates the humoral or TH2 arm of the immune system. Humoral immunity in overdrive is when the B cell derived plasma cells produce an over-abundance of ineffective antibodies. It is kind of like a car stuck in the mud and spinning its wheels in ever increasing speeds until the engine breaks finally down from exhaustion.
Acquired Immune Deficiency Syndrome is also a misnomer. The disease called AIDS should be renamed "Virus-induced Immune Exhaustion Syndrome" or VIES. The difference in theories as to the cause of "AIDS" is profound. The current model implies that the HIV virus directly attacks and weakens the immune system. This implication has never been scientifically proven. Medical researchers know that when they place the HIV virus in a Petri dish with white blood cells and CD4 T cells that nothing happens. So how then does HIV cause AIDS?
HIV causes AIDS by simply being in the body as a foreign presence. HIV is not pathogenic; that is, it does not directly kill any cells. It presence is like a red flag in front of a bull. It drives an antibody response (TH2) by just being there as well as constantly mutating. The T cell type 2 response (TH2) strongly activates inflammatory cytokines including nuclear factor kappa B (NF-Kappa B), tumor necrosis factor a (TNF-a) and interleukin 6 (IL-6). This leads to the continuous overworking of the CD4 helper cells and thus shortens their life span. If the immune system could be taught to ignore HIV, this virus would never cause AIDS and would in and of itself cause no illness.
This is a profound concept and is the basis for using anti-inflammatory immune-based therapies that reduce and even suppress TH2 type immune activity. AIDS is not a disease of immune deficiency, but rather one of immune exhaustion. In a few words, the CD4 helper cells and other white blood cells literally work themselves to death to remove this foreign entity called HIV that is perceived as a threat. The evolving realities of what AIDS really is calls for an immune-based therapy that is a tranquilizer for the immune system to give it a rest and stop the apoptosis (death) of the T cells.
AIDS is not caused directly by HIV, but rather by the immune systems reaction to the presence of HIV, a virus that is actually benign and "harmless in a laboratory."
Today's faulty disease model implies that HIV destroys the immune system single-handedly and causes AIDS. Nothing could be further from the truth. This flawed disease model feeds the sales of patented drugs that continue their relentless attack against this harmless virus while patients continue to die from immune dysfunction or the side effects of the drugs they have been told they must take all their life or until death do they part. For many, these words are all too true.
For pulsed therapy or short-term use, the strictly ant-viral drugs for HIV are beneficial as they reduce the foreign presence or stimulus that drives the inflammatory immune reaction. For continuous long-term use the antiviral drugs are self-defeating as they can kill the patient just as surely as an immune system that is over-stimulated by the presence of HIV.
Why patients with CD4 counts above 350 are told they must take their antiviral meds until death do they part when the government guidelines state to start taking the anti-HIV meds only when the CD4 count first drops below 350. This is a contradiction. When a person is first diagnosed with HIV and the CD4 counts is above 350, the person is not required to take the meds. However, when the CD4 count drops below 350 and you take the meds and the CD4 count climbs to 400 or 500 or higher, why are you not told to stop using the meds until the CD4 count again drops below 350? The answer is money. More drugs sold means more profits for the pharmaceutical companies.
In the last issue of JOI, we wrote about one person's long term experience with Composition A for his HIV. An analysis of Composition A and a similar product called "Resist" by Pacific Biologicals indicates that the first two ingredients in both formulas are Reishi mushrooms and the herb Astragalus.
Reishi is considered one of the most therapeutic mushrooms in Chinese medicine and Astragalus is widely used to improve the functioning of the white blood cells in their scavenging capacity to kill off foreign intruders as well as to increase the number of WBCs. Reishi supports adrenal function. Both Reishi and Cordyceps are anti-inflammatory and increase strength and endurance.
Some people prefer to take Chinese herbs like Reishi, Astragalus and Cordyceps separately to measure their effects instead of in premixed formulas.
Astragalus is used in formulas to treat hepatitis and other viral infections while Reishi has been used with success in cancer treatments. Reishi and Astragalus should benefit and help balance immune function in persons with cancer, HIV/AIDS, chronic fatigue syndrome, lyme disease and candidiasis.
In contrast, echinacea which improves humoral immunity and is beneficial for colds and flu's is contraindicated for use in HIV, cancer and other conditions where humoral immunity is already overactive.
Iodine is the most important mineral used by the thyroid to produce thyroxin, the hormone that controls body temperature and the metabolic rate. As iodine increases the thyroids secretion of thyroxin, the thyroxin induces IgA that provides protective mucosal immunity in the gastrointestinal tract. Increased thyroxin also helps with cellular antigen presentation and improves cell-mediated immunity. In addition to these metabolic and immunological benefits, iodine can have a systemic effect in killing bacterial, fungal, parasites and viral infections. Iodine joins 3% hydrogen peroxide and raw garlic as two other very low cost antibiotics that are highly effective, safe to use and readily available worldwide.
A letter appearing in the Intl Journal of Infectious Disease in Sep 2005 by Mamo and Naissides is titled "Could Iodine be effective in the treatment of human immunodeficiency virus and AIDS-related opportunistic infections?" The title of the letter raises the tantalizing possibility that iodine may help directly attack the HIV virus as well as improve cell mediated immune responses needed to prevent progression to AIDS. Combining the daily use of iodine with hydrocortisone, a $10 a month treatment, is a synergistic combination with possibilities for treating HIV, Chronic Fatigue Syndrome, Candidiasis and just maybe cancer in its earlier stages. Who will fund such a study and will anyone listen to the results if it is successful?
The local medical library did not have a copy of the letter as this issue of JOI goes to the printers, so this article continues with a discussion of my personal experience of using iodine to treat athlete's foot and to help normalize my body temperature.
Early in September, 2006, I began to have a recurring problem with itchy feet that I recognized as "athlete's foot." The condition got its name from persons who walk barefoot in a public locker room and shower area where the feet pick up fungus that are spread by other athletes. Fungal infections can also spread to other parts of the body when clothing is tightly worn and moisture accumulates. (E.G. jock itch and for women, vaginitis).
Skin types of fungal infections are treatable with antifungal medications (i.e. Lotrimin for athlete's foot, jock itch) where internal yeast infections are treatable with caprystatin, coconut oil, oil of oregano, lapacho, and raw garlic or with prescribed medication like Nystatin.
Systemic yeast infections can affect the entire gastro-intestinal tract from the mouth to the anus and circulate in the blood stream as well. Systemic yeast infections can also cause itching and rashes on the skin in various areas where fungal infections normally do not occur such as the arms, chest, thigh area and legs.
About a month ago, I began to ask myself what I was doing wrong. After all I was taking 400 mcg daily of phytosel, a 100% plant based selenium that boosts neutrophil activity that controls candida albicans. However, I had been eating more than my usual amount of sweets and the sugar fed the yeast growth.
I began to use GOOT, a garlic based salve that also contains Neem Seed oil, a powerful fungicide. I noticed beneficial results in a few days but when I stopped using the GOOT, the itchiness in my feet returned. Perhaps I hadn't used it long enough before stopping.
As I thought over the problem, I decided to test my body temperature. It was running about 1 degree below normal. I then decided to test my iodine levels using a self-test by painting iodine solution on my skin.
About a year ago I had used the iodine solution topically for several months. As I recall I had no problem with athlete's foot. However, at the time the thought of an association between the use of the iodine and the disappearance of the athlete's foot had not yet crossed my mind.
After several weeks of not using the topical iodine this summer, the athlete's feet condition flared up. This happened even while I had using kelp. Apparently the amount of kelp I had taken (2 capsules a day) was not sufficient for my iodine needs.
Using a 2% tincture of iodine solution I obtained from a local drug store and a Q-tip to apply it to my skin, I applied about a 2 inch by 2 inch round circle to my chest. I used the iodine that leaves a yellow- orange color on the skin. A clear iodine product is also available in drug stores but you cannot read it visually to determine your iodine status so you need to buy the colored iodine solution.
I found that within 3 hours the orange iodine strain had completely disappeared meaning that I was very deficient in iodine. The next day I applied it once more and again it vanished in a few hours. The altmedangel site stated that if the iodine circle vanishes in less than 4 hours that you are iodine deficient. The test then also becomes the treatment for the iodine deficiency condition. After about 2 weeks of applying the iodine solution to my skin daily, the time for complete absorption increased to almost 24 hours. I then stopped applying the iodine on a daily basis but will retest it once a week.
Surprisingly, the athlete's foot problem disappeared gradually over the first 3 days of painting the iodine solution on my skin. This happened even though the iodine was never applied to my feet. Apparently the iodine absorbed into my body through my skin had a systemic effect in killing off the candida albicans circulating in the blood stream and having settled in my feet.
My body temperature also returned to a normal 98.6 degrees F during the day and I felt much warmer all over. The iodine painted on my skin had a faster therapeutic effect than did the thyroid medication I had taken a few years ago. I discontinued the _ grain thyroid supplement about a year ago after I first started painting iodine solution on my skin. It was about a month after I had stopped using the iodine solution this summer that the athlete's foot problem resurfaced.
I am convinced that the needs for iodine will vary from person to person. Persons with viremia and chronic infections with high titers will need more supplemental iodine as the iodine will interact with the infectious agents in the blood and lymph fluid and bind the iodine making it unavailable to the thyroid. As the level of the infection declines so will the need for iodine also decline. This will show up on the skin as a slower absorption rate of the painted iodine.
I have talked with many people in the past several years who have had a lifetime struggle with candida albicans and fungal infections. Nearly all of them suffered from low body temperature. These people often had high titers for HHV-6, CMV. EBV and/or other chronic infections.
Could painting a circle of iodine solution on the skin daily help get rid of the candida albicans, parasites, HHV-6, herpes, hepatitis and multiple other bacterial, fungal, parasitic and viral infections including HIV?
1. Dip a cotton ball into USP Tincture of Iodine. (You can get iodine at the drugstore for under $1.)
2. Paint a 2 inch circle of iodine on your soft skin, like the inner part of your thigh or upper arm.
3. Wait. -- If the yellowish stain disappears in less than an hour; it means your body is lacking crucial iodine and has soaked it up. If the stain remains for more than four hours, your iodine levels are fine.
Low iodine levels can zap your energy and make you feel tired, edgy and worn out. Low iodine levels can even prevent you from getting a good night's sleep. Before you go to your doctor with complaints of tossing and turning all night, aches and pains, and just feeling "blah," you may want to perform this self-test.
Because the symptoms of an iodine deficiency are classically identical to so many other illnesses (like depression, stress, chronic fatigue, or fibromyalgia,) many doctors either misdiagnose it or miss it completely and tell you there is nothing wrong.
About 60% of all iodine in the human body is stored in the thyroid gland at the base of the neck. A Goiter, an enlargement of the thyroid gland, can occur when iodine deficiency is prolonged over a period of time. Iodine is the most important mineral used by the thyroid gland to produce thyroxin, a hormone that regulates the metabolic rate of energy production in the cells.
Iodine deficiency and a resulting insufficient production of thyroxin is linked to a wide range of illness form chronic infection of all types including candidiasis, herpes, bacterial, fungal and viral infections.
Table salt is iodized and is a source of iodine. However, excess sodium intake from salt consumption is a toxin and impairs the production of energy in the cells. Excess sodium intake is linked to metabolic syndrome including obesity, high blood pressure, heart disease and cancer.
The best sources of iodine are from sea vegetables and seafood including ocean fish. Unfortunately, most people do not consume iodine rich foods on a daily basis. Low body temperature and long term chronic infections may be directly linked to a deficiency of iodine and an impaired thyroid function.
Why are iodine levels so important?
Low levels of iodine mean your thyroid isn't functioning properly. The thyroid helps balance hormones, regulate heartbeats, stabilize cholesterol, maintain weight control, encourage muscle growth, keep menstrual cycles regular, provide energy, and even helps you keep a positive mental attitude.
Women are naturally prone to iodine deficiencies. That's because the thyroid gland in women is twice as large as in men -- so under normal circumstances, women need more iodine. However, when women are under stress, the need for iodine can double or triple. Yet the foods we eat contain less and less dietary iodine. For example, back in 1940, the typical American diet contained about 800 micrograms of iodine. By 1995, that amount plunged to just 135 micrograms. That's an 83% decline.
Two thirds of the body's iodine is found in the thyroid gland. One of the best ways to boost your iodine levels is to add seaweed sea vegetables to your diet. Just one teaspoon of sea vegetables a day can help you regain normal iodine levels. Incorporating seafood and fish into your diet can also help. Other foods that contain iodine are eggs and dairy products, including milk, cheese and yogurt, onions, radishes, and watercress. Some foods, called goitrogens, should be omitted for awhile as they hinder iodine utilization. These included kale, cabbage, peanuts, soy flour, Brussels sprouts, cauliflower, broccoli, kohlrabi and turnips.
To reactivate the thyroid gland, tyrosine, iodine, zinc, copper and selenium are needed so make sure that foods containing these nutrients are included in your diet.
Editor's note: The RDA of iodine is 150 mcg. That is just too little, in my opinion. Ideally, the average daily intake of iodine should be closer to 1000 mcg daily and higher than that for stress conditions that rapidly deplete iodine levels. Persons with systemic infections will need higher amount of iodine as this trace mineral will be rapidly bound to the infectious agents (bacterial, fungal or viral) in the process of destroying them thus leaving less iodine for the thyroid to pick up. While most people have an under active thyroid, a few people have an overactive thyroid but there is no research linking this to excess iodine intake.
Persons with Graves disease or overactive thyroid may need to check their saliva and urine pH levels and at the same time to see if they deviate and in which direction - above or below 6.4. Follow the diet plan to balance the pH in the Immune Restoration Handbook.
Consuming too much iodine is not the cause of Graves or hyperthyroid. I doubt that an over-active thyroid can exist without food sensitivities at the same time. Food sensitivities may be the driving force behind an overactive thyroid and higher than normal heart (pulse) rates. Be tested for food allergies - this is very important OR self-test: Eat only one food or drink per meal and test your pulse rate before and 10 minutes after eating or drinking. If the pulse rate increases by more than 10 beats per minute, avoid that food or liquid beverage (soda, coffee etc). The most common foods eaten daily are likely to be the source of the problem (milk, wheat gluten etc).
Consider the Rotation diet - eating the same food only once every 4 or 5 days. Persons who are acidic will need an alkalizing diet. High pulse rates can usually be reduced by taking a tablespoon of blackstrap molasses once or twice daily. Avoid all diet soda, aspartame, caffeine (coffee, tea, coke), alcohol and white sugar. Eat good carbs that are high in fiber. Supplements: Fiber and probiotics mixed, Coral calcium, magnesium oxide, plant-based selenium or Brazil nuts, sea vegetables. Drink bottled Spring water. Cook foods only in stainless steel or Pyrex pans (no Teflon). Be monitored by your physician.
Seafood and sea vegetables have the most while milk is also high in iodine. An example is 5 ounces of COD that has about 160 mcg of iodine whereas 8 ounces of yogurt has about 140 mcg of iodine. Ground Kelp contains about 400 mcg of iodine per 500 mg capsule. Regular elemental iodine and iodide taken orally including Lugol's solution can sometimes irritate the stomach. Absorption through the skin eliminates this problem when using a liquid iodine solution such as 2% iodine tincture from a drug store. Whole food sources do not upset the stomach.
The following is excerpted from healthlounge.net
This is not an all-inclusive list of all of the sea vegetables, but the most popular, healthy, and probable varieties that you will find in your grocery store.
Similar to wakame, alaria is often used as stock in soups. Alaria is very high in calcium content, comparable to whole sesame seeds. It is also extremely high in vitamin A, iodine, bromine, and B-vitamins.
Takes the form of long, thin strands and has a slightly sweet taste. It is a potent source of iron, calcium, potassium, and is one of the best sources of iodine. It is known to lower high blood-pressure.
Has a strong, rich ocean flavor and combines great with grains and in stock. Dulse is 22% protein, which is higher than garbanzo beans, whole sesame seeds, and almonds. Dulse is an alkalinizing vegetable and is a great source of vitamin B-6, B-12, iron, fluoride, potassium, phosphorus, manganese, and iodine.
Has a strong, yet appetizing flavor sweetens slightly when cooked. It is the riches of all the sea vegetables in nutrition. It is the highest mineral content and is extremely high in calcium, as well as iron and protein.
Similar to wakame and is a natural source of glutamic acid, which allows it to cook quickly and soften foods that it is cooked with. Kelp is often ground into powder and used in fertilizer due to its high mineral content. It is a great alternative to salt and is high in calcium, potassium, magnesium, iron, trace minerals (including manganese, chromium, and zinc), and iodine.
Similar to kelp and is also a great source of glutamic acid. Kombu is often served with beans because in contains enzymes that break down the raffinose sugars in beans that cause gas, bloating, and flatulence. Kombu has the ability to lower blood pressure, and is high in iodine, potassium, calcium, and vitamins A and C.
Has a mildly nutty and sweet taste and is best known as the wrapping of sushi. Nori is 28% protein and is a great source of calcium, iron, manganese, fluoride, copper, zinc, B1, B2, B3, B6, B12, and vitamins A and C.
Traditionally added to miso soup, this sea vegetable has a sweet flavor. Wakame is highly similar to kombu and has a very similar nutritional composition. It is high in calcium and contains high levels of the B vitamins and vitamin C.
Kawana R, Kitamura T, Nakagomi O, Matsumoto I, Arita M, Yoshihara N, Yanagi K, Yamada A, Morita O, Yoshida Y, Furuya Y, Chiba S.
Dermatology . 1997;195 Suppl 2:29-35.
Morioka Yuuai General Hospital, Japan.
Inactivation of a range of viruses, such as adeno, mumps, rota-, polio- (types 1 and 3), coxsackie-, rhino-, herpes simplex, rubella, measles, influenza and human immunodeficiency viruses, by povidone-iodine (PVP-I) and other commercially available antiseptics in Japan was studied in accordance with the standardized protocol in vitro. In these experiments, antiseptics such as PVP-I solution, PVP-I gargle, PVP-I cream, chlorhexidine gluconate, alkyldiaminoethyl-glycine hydrochloride, benzalkonium chloride (BAC) and benzethonium chloride (BEC) were used.
PVP-I was effective against all the virus species tested. PVP-I drug products, which were examined in these experiments, inactivated all the viruses within a short period of time. Rubella, measles, mumps viruses and HIV were sensitive to all of the antiseptics, and rotavirus was inactivated by BAC and BEC, while adeno-, polio- and rhinoviruses did not respond to the other antiseptics. PVP-I had a wider virucidal spectrum, covering both enveloped and nonenveloped viruses, than the other commercially available antiseptics.
Harbison MA, Hammer SM.
J Acquir Immune Defic Syndr . 1989;2(1):16-20.
Infectious Disease Section, New England Deaconess Hospital, Boston, Massachusetts.
Eleven povidone-iodine-containing products (Betadine) and chlorhexidine gluconate solution were tested for their ability to inactivate human immunodeficiency virus (HIV) in a cell culture system. All Betadine products completely inactivated the virus at povidone-iodine concentrations of greater than or equal to 0.5% (10- to 20-fold dilutions of stock) except for Betadine Lubricating Antiseptic Gel, which required 2.5% for efficacy (1:2 dilution).
Wood A, Payne D.
J Hosp Infect . 1998 Apr;38(4):283-95.
Results indicate that all products were effective in inactivating the enveloped viruses herpes simplex virus type 1 and human immunodeficiency virus type 1, whilst being ineffective in inactivating human coronavirus..Four antiseptic/disinfectant solutions with chloroxylenol, benzalkonium chloride, cetrimide/chlorhexidine and povidone-iodine were also assessed for antiviral effect against human immunodeficiency virus in the presence of whole human blood. All four solutions proved to be effective within 1 min despite the cytotoxic nature of the compounds to the detection system.
Note from Mark Konlee: A few years ago I talked with 2 persons from different parts of the country who have been on an unusual diet for several years with striking similarities and results. They ate no meat and ate seafood, fish and or sea vegetables daily for several years. They were also both HIV positive and non-progressors and neither person had used prescribed antiviral drugs for HIV. Could the iodine and other trace minerals in the seafood they consumed have had something to do with their status as non-progressors? Could eating sea vegetables and ocean fish daily help stop HIV progression to AIDS? Perhaps it is no coincidence that the Japanese and Koreans who consume sea vegetables and ocean fish several times a week are some of the healthiest people on the planet.
The Board of Directors (Conrad LeBeau, Patrick Raess and Tina Otto) met on September 16, 2006 and adopted a resolution to expand Keep Hope Alive's mission to include the following.
C. LeBeau / M Konlee
The expanded resolution covers our petition to the U.S. Congress to pass a law approving a series of peace initiatives to obtain a ceasefire in Iraq, direct dialogue with all parties to the conflict including representatives of insurgent and even "terrorist" groups to work out a political settlement to end the conflict and reach an agreed plan for the withdrawal of all foreign forces including Al-Qaeda and the Jihadists along with US and Coalition forces, the release of prisoners and verification of the withdrawal on a province by province basis provided by volunteer peacekeeping troops from the Arab League.
While the plan is complex, it has to be promoted by someone in authority to have any chance of success. It could salvage what is now a human disaster in Iraq and end the future carnage of a war that has no apparent end in sight. Readers of this newsletter are encouraged to make copies of the plan now posted on our internet web site at keephopealive.org and send them to their elected leaders, the "White House" and the national news media.
Sometime in the coming months, we are planning a link on our website to a Keep Hope Alive Forum where these and many other national and international issues will be discussed and proposed solutions will be offered as petitions to our elected leaders or letters to the media.
Individuals must stop feeling powerless to change the world and began asserting themselves as a counterweight to the negative forces that are leading our planet on a dangerous course of a clash of civilizations.
Edmund Burke, who for decades was quoted by the Hearst owned Milwaukee Sentinel, said it best: "The only thing necessary for the triumph of evil is that good men do nothing."
While silence equals death and darkness equals despair, let us change our planet one brick at a time and build a foundation of hope, healing and justice for all. Doing nothing is not a responsible option; it is a waste of our God-given talents and time. We must embrace the golden rule to do unto others as we would want others to do unto us. Wisdom and dialogue must replace the weapons of war and a meeting of minds must replace a multitude of missiles. Forgiveness must replace the cycle of revenge. In the words of St Francis of Assisi:
"Lord, make us an instrument of your peace.."
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